Evaluation Irisin Level and other Biochemical Parameters in Chronic Kidney Patients Before hemodialysis

Abstract

Background: The browning of adipose tissue is regulated by the myokine irisin, which plays a role in energy metabolism. This research set out to determine whether there was a correlation between patients' irisin levels and their pre-dialysis biochemical parameters in stage 5 chronic kidney disease (CKD). Methods: The study included 30 individuals with CKD in stage 5 before dialysis and 30 subject as control group, the ages of all patients and the control group ranged from (25-60) years. Excluded criteria included patients with viral hepatitis, diabetes.. Serum irisin concentration and the level of glucose (Glu), urea, creatinine (Cr) ,albumin  (Alb) , ACR ,TC, ALT,AST,ALP , Electrolytes ,Ca, PO4 and Vit D  were measured. Results: In the present study, the results showed significantly reduced in serum irisin , Vit D, Na , K. Ca.,AST ,ALT, eGFR ,Tp , Weight and a  significantly increased in Urea ,Cr, ALP. PO4 of patients was compered with control group, also results showed a  significant negative correlations between serum Irisin and FSG ,Cr,Ca,PO4,Alb,Urea,ALT levels in CKD group. While, significant positive correlations were found between serum Irisin and Age, Weight, Hight ,BMI, Tp, Chol, AST, ALP, Na, K, Vit D levels in CKD as well as, a significant negative correlations between Vit D and FSG, Cr, PO4,Alb,Urea, Chol., ALT, ALP ,Na  levels in CKD group . While, significant positive correlations were found between Vit D and Age, Weight ,Hight ,BMI, Ca, Tp, ,AST, K levels in CKD group. Conclusion: eGFR, body mass index, calcium, sodium, potassium, aspartate aminotransferase, tyrosine phosphatase, irisin, and vitamin D all rose dramatically as CKD advanced. Urea, creatinine, alkaline phosphatase, and phosphorous all went down. These results raise the possibility that irisin has a role in controlling biochemical factor levels in people with CKD. The ROC curve for irisin demonstrated a flawless cut off value, with a sensitivity of 87% and a specificity of 99.9%, indicating its potential as a diagnostic marker. For patients, a number less than 23.2 is considered indicative of poor health. As compared to the outcomes of urea and creatinine, Irisin's stood out as particularly intriguing.