Assement of Sclerostin and Some Biochemical Parameters in Growth hormone deficiency children

Abstract

A healthy skeleton depends on the preservation and continuing renewal of bone tissue. Bone resorption and bone production are carefully balanced during the highly controlled process of bone remodeling. Sclerostin and other Wnt pathway inhibitors play critical roles in regulating bone formation and resorption since the Wnt signaling pathway is one of the most essential routes regulating bone metabolism. Researchs examining the role of sclerostin in children with growth hormone deficiency is scarce. The aim of this study is to find out the relationship between sclerostin and its role as an important bone marker with growth in toddlers with a deficit of growth hormone. In the study 120 children participated, including sixty patients and sixty controls. Sclerostin showed a significant decrease in the patients. Therefore, this study was conducted to provide a better knowledge of the factors that affect kids who lack growth hormone.