''Effect of Tranexamic Acid on Hemorrhage in preeclamptic women during cesarean section (CS)''

Abstract

Objective; To assess the efficacy and safety of preoperative Tranexamic Acid in the reduction of blood loss during and after elective lower segment cesarean delivery among preeclamptic cases.

Methodology: 50 pregnant women, candidate for LSCS, were received Tranexamic acid in form of 1 gm (10 ml) TXA diluted in 20 ml of Glucose 5% (administered as intravenous infusion over 5 minutes, at least 15 minutes prior to skin incision immediately before starting skin incision. The 1ry outcome was the estimated blood loss (EBL) during cesarean delivery and 2ry outcomes included the occurrence of excessive blood loss (> 1000 mL) within the first 24 hours postoperatively and the occurrence of any maternal or fetal side effects.

Results: the mean age and BMI were 29.59 years old and 34.02 kg/m2 respectively, the mean GA at termination was 38.51weeks, the mean preoperative Hb was 11.17 gm/dl , postoperative 10.39 gm/dl and hemoglobin drop -0.78 gm/dl, the mean preoperative was 32.47 (%), postoperative was 30.66 (%), and hematocrit drop -1.80 (%), the mean EBL was 802.36 ml and mean Blood loss in suction 266.09 ml. The percentage of cases as regard the occurrence of side effect was 2%, the mean Apgar scores at 1 min was 7.1. Also, the mean Apgar scores at 5 min was 9.2.

Conclusion: Intravenous Tranexamic acid reduce the intraoperative blood loss and postpartum hemorrhage, in addition to this there was no evidence of any side effects only one patient developed mild hypersensitivity side effects from Tranexamic acid.