Investigation the antioxidant and anti-inflammatory effects of star anise essential oil and anethole against arsenic induced myocardial ischemia in male rabbits

Abstract

Star anise (Illicium verum Hook. f.) is a well-known widely used in our daily diet and  recently is   considered   gained importance as a medicinal plant which has important biological properties, especially the phenolic and the volatile constituents,  The current study was aimed  to assay  the   protective effects of essential  oil of star anise and anethole against deleterious effect in male rabbits exposed to arsenic. 30adult male rabbits were divided equally into five groups (six rabbits in each group): groups one and two   (the normal control group) rabbits received normal saline and DMSO,  group three rabbits were given sodium arsenate 10mg/kg of rabbit body weight, groups four and five  (the protected groups) rabbits received anethole and star anise oil  (250mg/kg)  for one week and then   same grouse  received  anethole and star anise oil  (250mg/kg) simultaneous with sodium arsenate  for 3 weeks, the doses once per day respectively. results  exhibited  that  oral exposure of arsenic cause to oxidative stress  evidenced by  markedly  elevation  in value of  oxidative index ( MDA) concomitantly with significantly  reduction  in total antioxidant capacity value, also results revealed that pronounced elevation  in  inflammatory biomarkers ( TNF-α and  CRP )  and  myocardial  function  indices( CTnI  and   CK,  LDH) values,  these alteration comparison to group  without  exposure  ( normal control ),  while the  findings of the study manifested that oral administration of anethole and star anise oil plus arsenic for 3 weeks   resulted in decrease the MDA value  with along an  increase in value of TAC this  is accompanied by markedly declined in inflammatory indices   and  restored  myocardial  function.  Conclusions: it can that Star anise (Illicium verum) administration cause to ameliorative myocardial function evidence by   reduction of inflammatory indices and subsequent blockade of the inflammatory response, the Illicium v. may be a useful a potent antioxidant and anti-inflammatory agents.