Histopathological changes in placental tissue of aborted women infected with Cytomegalovirus and Toxoplasma gondii

Abstract

The placenta is an organ that develops alongside the fetus, providing nourishment and removing waste products via the blood supply to the mother and the placenta has a crucial role in determining the health and development of the fetus. Therefore, this study was conducted to study the histopathological changes in the placentas of aborted women infected with Toxoplasma .gondii and Human Cytomegalovirus. Where the study samples were 30 samples of placentas from aborted women in the curettage room who had positive serological results for anti- Human Cytomegalovirus and anti-Toxoplasma gondii IgG and IgM to study histopathological changes during the period from 1/2/2022 to 30/7/2022. Small pieces of placenta tissue were taken to prepare 3-μm-thick tissue sections. All slides were stained by routine hematoxylin and eosin stains and then evaluated by experienced pathologists for different types of placental lesions. Ten samples were taken from pregnant women who gave birth naturally, representing the control group. The results of the study showed clear pathological changes represented by the presence of Polymorph neutrophils ; Lymphocytes and Hofbauer cells in the placenta infected with Human Cytomegalovirus and Toxoplasma gondii. and tissue cysts in the placenta infected with Toxoplasma gondii only. So, the histopathological changes were more severe in the placenta infected with Human Cytomegalovirus and toxoplasma gondii at the same time because of the weak immunity of the aborted mother, followed by the placenta infected with toxoplasma gondii, which showed severe histopathological changes compared to the placenta infected with Human Cytomegalovirus.