Correlation of Umbilical Artery Doppler Indices and Neutrophils to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Red Cell Distribution Width, Mean Platelet Volume to the Severity of Preeclampsia

Abstract

Study Objective To explore the relationship among umbilical artery Doppler indices and certain hematological parameters (NLR, MPV, PLR and RDW), and the severity of preeclampsia. Methods This was a prospective cross-sectional study. Nine hundred and fifty pregnant women were included and divided into severe preeclampsia group (200), non-severe preeclampsia group (250) and control group (500). Umbilical artery Doppler indices as well as the hematological parameters were measured. Neonates were assessed as regards APGAR score at 1 and 5 minutes and neonatal birth weight. Results Umbilical artery RI and PI showed positive correlation with SBP (r=0.156 and 0.218, P value=0.019 and 0.002, respectively). Each of the UA RI, PI and S/D were significantly negatively correlated with AFI, APGAR 1 minute, APGAR 5 minute and NBW ( RI correlations: r= -0.572, P value ˂0.001: r = - 0.319, P value ˂0.001: r= -0.357, P value ˂0.001; r 0.357, P value ˂0.001; r= - 0.596, P value ˂0.001, respectively; PI correlations: r= -.0397, P value ˂0.001; r= -0.288, P value ˂0.001; r= -0.304, P value ˂0.001; r= -0.426, P value ˂0.001, respectively; SD correlations: r= -0.525, P value ˂0.001; r= -0.405, P value ˂0.001; r= -0.463, P value ˂0.001; r= -0.466, P value ˂0.001, respectively). NLR showed significant negative correlation with APGAR score at 1 minute and NBW (r= -0.162, P value=0.022; r= -0.237, P value = 0.001). Conclusion UA Doppler indices correlate with the severity of preeclampsia and the neonatal outcome. Neutrophils to lymphocytes ratio is the only hematologic parameter that correlates with neonatal outcome.