Caspase-3 level is associated with bacterial prostatitis in male infertility

Abstract

Background: Bacterial prostatitis (BP) is an infection of the prostate gland if not treated appropriately it lead to significant morbidity and is associated with some complication like recurrent Urinary Tract Infection (UTI) and infertility.

 Objective: The aim of this research was to evaluation of caspase-3 level in serum of infertile males infected with bacterial prostatitis.

Patients and method: The study was done at Infertility Unit, AL-Sadder medical City, Al-Najaf City, Iraq during the period from January to June 2022 included 120 individuals divided as follow: 60 patients were infected with prostatitis and 30 were infertile and 30 healthy as control group. Caspase-3 serum levels were measurement by enzyme-linked immunosorbent assay (ELISA). A loop full of semen has been cultured to bacterial identified.

Results: The results of the current study revealed that Escherichia coli (E.coli) was the first etiological agent caused prostatitis 30(33.2%) and the levels of serum concentration of caspase-3 was significant increase (P<0.05) in patients with infertile (29.3±1.092), prostatitis infertile (41.55 ±3.452) and prostatitis patients (22.12 ± 1.572) in comparison with a healthy group (10.5 ± 0.4680).

Conclusion: The current study has concluded that prostatitis was associated with multiple etiologies and pathways, most of which resulted from interactions with the immune system and male infertility.