Formulation and Characterization of Cariprazine Nanoemulsion as Oral Route

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Hiba Ezzat Hamed

Abstract

 


Cariprazine is a antipsycotic drug with low aqueous solubility.  Nanoemulsion (NE) is one of the popular methods that has been used to solve the dispersibility problems of many drugs. Cariprazine was formulated as a NE utilizing oleic acid as an oil phase, tween 80 and tween 60 as surfactants and ethanol as a co-surfactant. six formulas were prepared, and different tests were performed to ensure the stability of the NEs, such as particle size, polydispersity index, dilution test, drug content, viscosity and in-vitro drug release. Results of characterization showed that cariprazine nanoemulsion (F3)  was selected as the best formula, since it has a particle size of (27)nm, low PDI (0.371), good dilution without drug precipitation , higher percent of drug content (98.9%) with acceptable viscosity , and complete release of the drug after (40 min.) with significantly higher (P<0.05) dissolution rate in comparison with the pure drug powder. The selected formula (F3) subjected to further investigations as drug and excipient compatibility study by Fourier transform infrared spectroscopy (FTIR) The outcomes of the (FTIR) indicates that there was no interaction between cariprazine and other NE components. Therefore, these excipients were found to be compatible with cariprazine. In conclusion, the NE was found to be an efficient method to enhance water solubility.


 

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Hiba Ezzat Hamed