Preparation and investigation of substance with polymer based nanoparticles

Abstract

Topical drug administration is very important delivery system to localize drug anywhere in the body through skin, ophthalmic, vaginal and rectal routes. The challenge of developing a topical product stems from many requirements like product stability, skin penetration and cosmetic acceptability. There are many topical drug delivery systems to overcome such problems like liposomes, cubosomes, niosomes, ethosomes and catezomes as nanoparticles. Since erythromycin is a potent antibacterial drug but still its topical usage needs further optimization. There is a wide range of pharmaceutical dosage forms available for topical drug - delivery systems. The particles of the dispersed phase form an interlaced three-dimensional network due to the interaction between the polymer and the liquid dispersion medium. That showed that F5 gave 26.15% drug release within 1 h and the release increasingly continued for the next 2 h (48.56%), which was better than other formulas, and this could be due to the presence of high amount of poloxamer 407 in F5.