Protective Role Of Gum Arabic (Acacia Senegal) Against Adenine Induced Nephrotoxicity In Male Albino Rats: Some Histological, Histochemical, And Biochemical Studies

Abstract

This study was amid to investigate the protective role of Gum Arabic (GA) on Adenine (AD)-induced
nephrotoxicity on the final body weight (b.w.), absolute kidney weight, serum concentrations of urea and
creatinine with malondialdehyde (MDA), besides histological and histochemical changes in the kidney tissue
of male albino rats. Twenty-four adult male albino rats were assigned randomly in to four groups (n=6 of
each): Group 1 (Control) take only normal saline, Group 2 (AD group 150 mg/kg b.w.), Group3 (AD +GA
10% w/v), Group 4 (AD +GA 20% w/v). The treatment was given daily via gavage orally for 30 days. AD
group showed a significant elevation of final b.w. and absolute kidney weight, urea, creatinine, and MDA
level in comparison with the control group. Kidney sections of rats administrated with AD showed dilation of
bowman’s capsule space, segmentation of glomerulus, necrosis, proteinaceous remnant, hyperplasia,
crystallization, and damaged urinary tubules. Histochemical sections of AD group showed depletion of
kidney protein and carbohydrates. On the other hand, both groups of GA in combination with AD revealed a
significant reduction in the serum urea, creatinine, and MDA level. In conclusion, these results suggest that
GA have a noticeable protective and antioxidant effect against AD nephrotoxicity.