A Formulative Approach on Premna latifolia Loaded Niosomal Gel for Wound Healing

Abstract

Premna latifolia are straggling or and climbing trees, shrubs, undershrubs, rarely herbs in the family Lamiaceae. The aim of this research work was to develop a niosomal gel by incorporating a novel drug carrier such as a niosome containing herbal extract for treatment in eye diseases like wounds. The niosomal dispersion was prepared by varying concentrations of two surfactants while the drug and cholesterol concentration was kept constant. The optimization of the niosome was done based on the size and shape of the vesicle obtained from SEM analysis. The optimized niosomal dispersion was then converted to a niosomal gel and evaluations were carried out like pH, viscosity, gelling capacity, gel strength, isotonicity evaluation etc. The drug-loaded niosomes were stable in HPMC, HPMC K15M, and Carbopol 940 gel, and the optimum HLB value of the surfactant span 60 made this formulation more stable. The formulation provided good permeation through the cornea while the adhesion property of gel improved the contact time within the eye.