Chitosan-Based Polymeric Nanoparticles of Lamotrigine for Solubility Enhancement

Abstract

A naturally occurring polymer, chitosan is mostly extracted from the shell of marine organisms. Due to its unique properties of low toxicity, biocompatibility, biodegradation, and low immunogenicity, chitosan is being employed extensively in the field of biomedicine. Chitosan nanoparticles can be easily formulated. In this work Development of nanoparticles and scaling up the formulation with its size atoms and molecules has been focused on. The achievement in therapeutic efficacy and fewer side effect has been achieved. In this current work, the targeted drug delivery for various diseases has been achieved by preparing the nanoparticles. The drug lamotrigine is used in increasing the efficacy of exerting cellular activities, to increase the adsorption of lamotrigine we have developed lamotrigine nanoparticles and we have confirmed that Nano formulation with analyzing FTIR, DSC, and solubility. Also, we have studied the same and particle size analysis with entrapment efficacy. The F2 formulation had shown the highest percent drug content with the highest entrapment efficacy. Lamotrigine showed 43.59% and formulation F2 showed 83.12% drug release at 90 min., which was linearly increasing concerning time. The release rate was increased almost by 44% significantly higher than that of pure Lamotrigine.