Metabolic Abnormalities of Obesity Induced by Monosodium Glutamate and Their Effect on Male Sex Hormones in Rats

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Sherif. Y. Saleh, Elsayed H. Eltamany , Eman. A. Elshamy

Abstract

This study aimed to identify the potentially negative impacts of monosodium glutamate (MSG) on male rat sex hormones and several biochemical markers. There were two primary groups made up of thirty male Sprague Dawley rats. The first group (n=15) was given distilled water (serves as negative control). The other group (n=15) received 15 mg/kg B.W. of MSG orally throughout a three-month period. According to results the amount of total testosterone (TT) significantly dropped In addition, Triacylglycerol (TAG), total cholesterol (TC), glycated haemoglobin (HbA1c), insulin, leptin, tumour necrosis factor alpha (TNF-), interleukin-6 (IL-6), liver enzymes, renal function, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were significantly higher than before. prolactin (PRL) levels did not alter, though. It can be said that MSG has severe effects on the liver, kidneys, lipid profile, and may be a factor in male infertility.

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