Assessment of some trace elements and their correlation among themselves and with TSH in Hashimoto's thyroiditis tissue samples

Abstract

Trace mineral analysis at the solid tissue level can provide more information than blood or urine analysis, revealing the role of minerals in organ-specific illnesses. The percentage of trace elements present in patient tissue samples was calculated using the X-ray fluorescence (XRF) technique. XRF is a rapid and easy approach to determining the presence of elements such as titanium (Ti), iron (Fe), nickel (Ni), cooper (Cu), zinc (Zn), and Cu/Zn at trace levels (less than 1 ppm). Hashimoto's thyroiditis (HT) is a type of autoimmune thyroiditis. Because the thyroid cannot produce enough thyroid hormone, your body cannot function properly. The results showed the concentration of trace elements in ppm as follows: Ti=0.0441±0.02, Fe = 0.04±0.027, Ni = 0.02±0.007, Cu = 0.17±0.036, Zn = 0.11±0.01and Cu/Zn = 1.53±0.229 ppm. The results refer to a significant positive correlation between Fe with Ti, Cu, Zn, and Cu/Zn and thyroid stimulating hormone (TSH), Cu with )Fe, Ni, Zn, and Cu/Zn(, and Ni with )Cu, Zn, and Cu/Zn( while there is a negative correlation between TSH and (Ti, Ni, Cu, Zn, and Cu/Zn) but the results are not significant except for TSH with Cu.