Evaluation of IL12 and IL-15 serum levels in alopecia areata patients in AL-Diwaniyah province

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Mary A. Tahseen, Suaad A. Fazaa

Abstract

Background: Recent theories have shown that some immune variants found in patients can be associated with Alopecia, especial alopecia areata type.


Objective: the aim of current study is to Detection, Assessment, Estimation of some hematological parameters in alopecia areata (AA).


Material and methods: A retrospective- study was performed from  July 2022 - February 2023. A total of 120 patients with alopecia to AL-Qadisiyah hospitals, private clinicals, AL-Karamah private hospitals in both sex and different age were studied. The serum was taken from the patients by drawing blood, and separating it with a centrifuge then applying immunological techniques on it.


Results: The results revealed that alopecia areata are 80(66.66%) sample , other types(the alopecia universalis and  alopecia totalis) are 40(33.22% ) sample, out of 120 samples. Through the results, immunological changes were found in patients with alopecia areata, the total WBC (8051.1 ± 376.22) , cell/mm3 ,as compared with the healthy control (7056.0 ± 249.6) cell/mm3. results of IgE 2.568±0.189 of patients and 0.043±0.022 , while Both IgG and IgM have an inverse correlation with the severity of the disease. level of interluiken 12 of pateints with alopecia  areata 472.69 ± 11.53a, patients with Universalis and totalis 339.63 ± 23.76a, compared with control(n=60)122.40±16.68b, level of interluiken 15 with alopecia areata was the highest 532.54± 22.54a , however the pateints with unevirsalis and totalis 464.55±45.98a , compared with control 118.55±23.51b.The results of CD4 pateints with alopecia areata was the highest 4.06 ± 0.93 compared with control 3.18 ± 0.65 , The results of CD8 pateints with alopecia areata was the highest (n=80)323.7± 127.3 compared with control group(n=60) 159.8±62.1


 Conclusion: the study highlighted, the presence of some immunological variables in patients that lead to alopecia and gives the basis for a larger and more complete study of immunological disorders in patients with alopecia areata or totalis.

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