Bovine Antibody Response to Respiratory Disease Caused by Mannheimia haemolytica Leukotoxin

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Suleman Khan, Sumyya H. Hariri

Abstract

In order to find out Mannheimia haemolytica was involved in outbreaks of bovine respiratory disease (BRD), a serological survey was done on paired (acute-convalescent) sera from 200 beef cattle and 250 dairy cattle during 10 outbreaks of BRD in Pakistani herds between 2021 and 2022.The sera were collected during BRD outbreaks in Pakistan. In the herds that were examined, there was no evidence of a vaccination programme against M. haemolytica A1. For each epidemic, a serum sample from five to ten animals was evaluated for collection. In order to evaluate the antibody response of the serum to M. haemolytica leukotoxin, an enzyme-linked immunosorbent test, or ELISA, was carried out (LKT). The seroconversion process was carried out on animals (54%), specifically 70 beef cattle (28%) and 55 dairy cattle (27%), respectively. It was determined by serological testing that M. haemolytica was involved in 10 (9%) of the BRD outbreaks. It ranged from 10% to 40% range for the prevalence of seroconversion. In 200 out of 510 total cases, there seemed to be evidence of a concurrent seroconversion to M. haemolytica and the primary bovine respiratory viruses. Cattle that had not been vaccinated against BRD viral agents were the most likely to develop antibodies against M. haemolytica LKT.

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