Antibacterial Activity Test To Ethanol And Aqueous Extracts Of Fruit Cucurbita Pepo On Multi-Antibiotic Resistance Bacterial Strains Isolated From Human Urinary Tract Infections

Abstract

Bacteria (Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, and Proteus mirabilis) identified biochemically from human urinary tract infections were used to investigate the antibacterial activity of aqueous and ethanolic extracts of the Cucurbita pepo fruit. The in vitro examination of antibacterial activity was performed using the Kirby-Bauer diffusion technique. For the first time, high to moderate antibacterial activity against Staphylococcus aureus and Escherichia coli was found in the ethanolic extracts of the Cucurbita pepo fruit. The aqueous extract, on the other hand, had a weak effect on Staphylococcus aureus. When tested on Klebsiella pneumonia and Proteus mirabilis, the extracts showed only a moderate amount of antibiotic activity. According to the results, treating bacterial UTIs with an extract from the Cucurbita pepo fruit may offer a novel source that may be utilized as an adjuvant to antibiotics.The aqueous and Ethanolic extracts of Cucurbita pepo fruit , were used as antimicrobial activity against multi-antibiotic resistance strains (Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, and Proteus mirabilis) which were isolated biochemically from human urinary tract infections. The in vitro antimicrobial activity was performed by using Kirby-Bauer diffusion. The ethanolic extracts of Cucurbita pepo fruit showed for the first time a high to moderate antimicrobial activity against Staphylococcus aureus and Escherichia coli respectively whereas the aqueus extract showed a moderate effect against Staphylococcus aureus only. Weak antimicrobial activity was seen on Klebsiella pneumonia, and Proteus mirabilis using both extract. The results concluded that the application of Cucurbita pepo fruit extract against human multiresistant urinary tract pathogens may represents a new source as adjuvant to antibiotics for effective treatment of bacterial urinary tract infections.