Synthesis Of New Hybrid Molecules Having AzoleMoieties And Evaluation Of Their Antimicrobial Activities

Abstract

Infectious microbes are attacking our health and spreading enormous types of virus, bacterial, and fungal-associated
life-threatening diseases. In this era of medicine, various categories of medicines are available on the market. Each
belongs to a different class, and each class has a different mechanism. In the present study, we synthesised a new series
of 2-aminobenzothiazole and benzimidazole derivative hybrid molecules to investigate their antimicrobial activities. IR
and 1HNMR confirmed the structures of synthesised azole derivative compounds. In the study, some newly synthesised
azole compounds were studied on different bacterial strains, and it was found that each azole compound has different
efficacy. The synthesised test compounds like T1, T3, T4, B5, and Tt2 showed good activity against gram +ve bacteria,
whereas T3, T4, T5, Bb1, and Tt5 showed good antibacterial activity against gram –ve bacteria, while T4 and Bb5
showed good results against fungi. Antimicrobial activity against some bacterial strains was measured by the broth
microdilution method.