Formulation, Optimization And Characterization Of Root Extract Of Gloriosa Superba Linn. Loaded Transdermal Patch

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Sangita K. Patel
Dr. Hitesh A. Patel


The aim was to formulate and evaluate methanolic root extract of gloriosa superb linn. Containing herbal transdermal patch by solvent casting method using polymer ethyl cellulose, 0.35% and 0.45% and a total of eight formulations were prepared and study on effect of polymer concentration on in vitro drug release profile. Plasticizer used was dibutyl pthalate with penetration enhancer PEG-6000. The transdermal patches were evaluated for their physicochemical properties like thickness, weight variation, % moisture content, water vapor transmission, % drug content uniformity, in-vitro drug release studies were performed by using Franz diffusion cell. The optimized formulation F4 contains 0.35% ethyl cellulose with dibutyl phthalate as plasticizer showed a maximum release of 99.89 in 12 hours. Out of these eight formulations of 0.35% ethyl cellulose was optimized concentration they produced sustain and complete release over a period of 12 hours due to 0.035% of PEG-6000 as penetration enhancer. The study indicated that the optimized formulation F4 has good effect of polymer concentration on in vitro drug release profile.

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Author Biographies

Sangita K. Patel

Research Scholar, Sankalchand Patel University, Visnagar

Dr. Hitesh A. Patel

Nootan Pharmacy College, Department of Pharmaceutics, Sankalchand Patel University, Visnagar, 384315