Main Article Content
The aim was to formulate and evaluate methanolic root extract of gloriosa superb linn. Containing herbal transdermal patch by solvent casting method using polymer ethyl cellulose, 0.35% and 0.45% and a total of eight formulations were prepared and study on effect of polymer concentration on in vitro drug release profile. Plasticizer used was dibutyl pthalate with penetration enhancer PEG-6000. The transdermal patches were evaluated for their physicochemical properties like thickness, weight variation, % moisture content, water vapor transmission, % drug content uniformity, in-vitro drug release studies were performed by using Franz diffusion cell. The optimized formulation F4 contains 0.35% ethyl cellulose with dibutyl phthalate as plasticizer showed a maximum release of 99.89 in 12 hours. Out of these eight formulations of 0.35% ethyl cellulose was optimized concentration they produced sustain and complete release over a period of 12 hours due to 0.035% of PEG-6000 as penetration enhancer. The study indicated that the optimized formulation F4 has good effect of polymer concentration on in vitro drug release profile.