Review Of Cetylpyridium Chloride Combination With Azadirachta Indica Extract Antibacterial And Antimicrobial Effervescent Mouthwash

Abstract

The objective of present work is to formulate and evaluate mouthwash and to evaluate its effectiveness against microbial load of oral cavity. The plant materials were collected and extracted for water soluble ingredients. Prepared mouthwash was further evaluated for its physicochemical properties and antimicrobial activity. The present mouthwash possesses a good antibacterial property. The results of stability study also confirm the effectiveness of preparation. Present mouthwash is a liquid preparation which normally contains antibacterial and antiseptic agents. These solutions can be used to reduce the microbial growth in the oral cavity Effervescent preparations may enhance absorption and speed up onset of action by increasing gastric pH, therefore hastening the emptying of medication into the small intestine. The carbon dioxide bubbles may also help intestinal absorption by opening up paracellular transport. Extreme bioavailability differences of up to 4-fold have been reported comparing effervescent tablets with ordinary tablets, highlighting the need for extra bioequivalence studies when switching dosage forms.