Formulation And Evaluation Of Antifungal Drug Loaded Solid Lipid Nanoparticle For The Treatment Of Dermatitis

Abstract

One of the most typical causes of skin problems is fungus infections. Infections caused by fungi are becoming more common everywhere. Therefore, solid lipid nanoparticles encapsulating antifungal medications were created in order to increase drug penetration, reduce drug side effects, and provide quick symptomatic relief from fungal infections. For better medication penetration through the stratum corneum and to increase the therapeutic effectiveness of the medicine, terbinafine- and cotrimoxazole-loaded solid lipid nanoparticles were produced and added to aloe vera gel in the current study. Utilizing a straightforward modified solvent emulsification approach, the TBF-SLN and CTZ-SLN were created. The novel excipients made up the TBF-SLN and CTZ-SLN. All the formulations were discovered to be in the nanometric range, spherical in shape, and capable of entrapping the most amount of medication. The TBF-SLN and CTZ-SLN optimized formulations were lyophilized and subjected to DSC, FT-IR, and XRD analysis. The outcomes show that the excipients and drug were complementary, that no interactions occurred, and that the crystalline drug and lipid were converted into amorphous SLN. To increase drug absorption and provide an additive impact in the treatment of a fungal infection, TBF-SLN and CTZ-SLN were added to aloe vera gel. Different physicochemical characteristics of the TBF-SLN gel and CTZ-SLN gel were assessed