Formulation & Evaluation Of Ozenoxacin Emulgel For The Treatment For Bacterial Disease

Abstract

Topical antibiotics represent an effective strategy for localized treatment of bacterial infections, minimizing systemic exposure and side effects. This study was designed to formulate and evaluate a 1% Ozenoxacin emulgel, a promising new treatment option for bacterial skin conditions. Three formulations were prepared using different gel-forming agents - Carbopol 934, Carbopol 940, and Hydroxypropyl Methylcellulose (HPMC), with each formulation evaluated for viscosity, spreadability, extrudability, and in vitro drug release.

Formulation C (HPMC) exhibited the highest viscosity (240±8 cP), which correlated with slower drug release, achieving 80% release after 8 hours. Formulation B (Carbopol 940) displayed optimal spreadability (9±0.8 cm) and extrudability (1.6±0.05 g), contributing to improved user application. Absorbance of Ozenoxacin was evaluated, with peak absorbance occurring at a wavelength of 250 nm.

This research underscores the significance of the choice of gel-forming agents in the formulation of emulgels, with clear implications for drug release rates and application properties. Further research is needed to refine these formulations and evaluate their therapeutic efficacy in vivo.