“Formulation and optimization of ornidazole loaded microsponge for vaginal drug delivery ”

Abstract

The aim of the present study is to formulate, development and characterization the Ornidazole microsponge by using Ethyl cellose by quasi emulsion solvent diffulsion method. Microsponge was made target specific release of the drug for vaginal drug delivery. 

Materials: Microsponge containing Ornidazole, Ethyl cellulose and PVA used for microsponge preparation. Different stirring rate i.e 500, 800, 1000, 1200  rpm used for preparation.

Objective: Particle size of prepared microsponge was observed by different method.  The production yield, entrapment efficiency and drug content were found to be above 70%. The impact of Drug: Polymer ratio and process variables i.e stirring speed and stirring time on the physical features of microsponges like production yield, mean particle size, entrapment efficiency were examined. It was shown that production yield, drug content and entrapment efficiency was found to be change with drug: polymer ratio.

Result: As the polymer concentration increased, thus increasing the thickness of the wall of the polymer matrix which lead to extended diffusion path and ultimately to lesser drug release or more sustained release. The effect of stirring rate on the morphology of  micro sponge.

Conclusion: The dispersion of the drug and polymer within the aqueous phase was found to be dependent on the agitation speed. As the speed was  increased the size of microsponges was reduced and the microsponges were found to be spherical and uniform.