Preparation and Evaluation of Flurbiprofen Based Microsponges

Abstract

Flurbiprofen(FP) is a medicine belonging to class of Non-Steroidal Anti- Inflammatory Drugs and is classified in class II of BCS having high permeability and low solubility. The end of present study was to formulate the flurbiprofen as a microsponge technology. Microsponges is used to increase the drug release. Flurbiprofen is the class II drug of BCS class having the High Permeability and Low solubility activity. In this Microspongial patented Drug Delivery System, Flurbiprofen drug loaded in cross linked polymers pore. The Quasi emulsion solvent diffusion method introduced for preparation of Flurbiprofen Microsponges. In this method, the internal and external phases employed. Where drug dissolved in mixture of Eudragit RS 100 and dichloromethane as a internal phase and this internal phase add in poly vinyl alcohol as a external phase. Throughout the process ultrasonication, stirring and filtration used to achieve microsponges. The percentage yield, FTIR, entrapment efficiency, dissolution test carried and to increase the entrapment efficiency and percentage yield drug polymer ration used