Pharmacological Evaluation Of Ibuprofen With Methotrexate In DENA Induced Hepatocellular Carcinoma

Abstract

This research was an attempt to examine the pharmacological role of ibuprofen and methotrexate combination against hepatic cancer in Wistar rats. One time DENA (200 mg/kg i.p.) was used for generation of liver cancer in wistar rats. The total rats were separated into five different groups. DENA received rats were given with unadulterated ibuprofen (40 mg/kg, p.o.) and methotrexate (5mg/kg, i.p.) for the duration of 18^th weeks. The procedure was ended by the 18^th week. Results were determined by the serum parameters and liver homogenate parameters. Additional, this combination of ibuprofen and methotrexate possesses the significant liver cells protective effect against DENA-induced hepatocellular carcinoma (HCC) by adjusting the liver enzymes and other biochemicals. The above results declared that ibuprofen and methotrexate combination has highly effective treatment of hepatocellular carcinoma