Pharmacological Activity Of Antifungal Drug Loaded Solid Lipid Nanoparticle For The Treatment Of Dermatitis

Abstract

Globally, fungus-related infections are on the rise. For fungal infections, oral medication is associated with side effects, a protracted course of treatment, and patient intolerance. In contrast, low drug solubility, skin irritation, and limited permeability via the skin are associated with superficial fungal infections and topical therapy. The goal of top topical therapy is to reduce adverse effects like irritation and provide quick symptomatic relief from fungal diseases while also enhancing the penetration of poorly soluble drugs. The current study formulated Terbinafine- and Co-loaded SLN to increase therapeutic action and improve penetration via the stratum corneum. A gel of solid lipid nanoparticles was made via high shear homogenization. There were excipients in the formulation. While continual release offers a long-lasting anti-fungal effect, the initial burst release offers a quick start to activity. Following the OECD's requirements, research on skin irritation was conducted, and the formulations were found to be safe and non-irritating for topical application. The anti-fungal activity and stability of the Terbinafine and Co-trimoxazole Solid Lipid nanoparticles gel were improved. Thus, solid lipid nanoparticles loaded with terbinafine and co-trimoxazole show promise as a drug delivery vehicle