Development, Characterization, And Evaluation Of Anti-Fungal Activity Of Nystatin Loaded Nanogel Prepared From Biodegradable Polymer

Abstract

One well-known fungal infection of the skin, topical candidiasis, is typically treated with traditional dose forms like cream, gel, or emulgel, which have a number of negative consequences on the skin. Novel medication delivery techniques have been explored as a means of mitigating these drawbacks. Systematic use of polymer-based nanoparticulate materials has demonstrated good skin penetration. Thus, the pathophysiology, etiology, and subsequently topical treatment of candidiasis were the primary foci of the current investigation. Using natural polymers like chitosan and gelatin, nanogel containing Nystatin has been created. Nystatin's 100 mg nanogel was created using a modified emulsification-diffusion process and was assessed for a number of factors. Out of the seven nanogel formulations denoted as F1 through F7, F1 has been chosen as the model formulation due to its high percentage of gelatine and chitosan (83.86 and 18.16, respectively). This was because the formulation F1 was determined to be optimal and stable in accordance with the ICH stability guidelines. The greatest release, or roughly 88.57%, was likewise demonstrated using Nystatin nanogel formulation F1. The prepared nanogel was shown by XRD to be crystalline. In conclusion, topical preparation and nano size are the two primary benefits of the Nystatin nanogel drug delivery systems. One theory is that the most effective treatment for fungal skin disorders might involve the use of nanogel.