Conventional To Modern Approach on Ketoprofen Formulation: A Comprehensive Review

Abstract

Pregabalin mucoadhesive microspheres were created and optimised with the use of Box-Behnken process optimisation software. Experimental data were obtained on the quantitative responses of particle size, entrapment effectiveness, and in vitro drug release for various combinations of independent variables, sodium alginate as a release retarding polymer, sodium carboxymethylcellulose as a mucoadhesive polymer, and calcium chloride as a cross-linking agent. The data were found to fit the design model. Polynomial equations could be used to estimate the quantitative impact of these parameters on the responses at various levels, and strong linearity was seen between anticipated and actual response variable values. According to the study's findings, the number of polymers and cross-linking agent had a significant and interactive impact on the responses, particle size, entrapment effectiveness, and in-vitro drug release. The design expert software's point prediction revealed the optimised formulation F3 to be the best formulation. It was discovered that the in-vitro drug release was under control for more than 12 hours and adhered to the Higuchi model. Three dependent variables had RSM validations of 99.76%, 98.78%, and 97%. As a result, it can be said that a three-factor, three-level Box-Behnken design was used to build and optimise a mucoadhesive microsphere for Pregabalin.