Unlocking The Potential of Aceclofenac: Investigating Strategies To Enhance Oral Bioavailability and Therapeutic Efficacy

Abstract

Oral bioavailability of aceclofenac is very low (only 14%) due to instability and incomplete intestinal absorption and extensive gut wall extraction. Aceclofenac, a potent NSAID, faces challenges related to its limited bioavailability, hampering its therapeutic efficacy. This study investigates the potential of naringin, a natural flavonoid known for its bioenhancement properties, to improve aceclofenac's bioavailability. Formulations of aceclofenac containing naringin were developed and characterized for physicochemical properties. In vitro dissolution studies revealed enhanced drug release rates compared to control formulations. Pharmacokinetic studies in animal models demonstrated significantly improved oral bioavailability of aceclofenac when co-administered with naringin, attributed to increased intestinal absorption and enhanced drug solubility. These findings highlight the promising role of naringin in augmenting the bioavailability of aceclofenac formulations. This approach holds potential for developing more effective oral dosage forms of aceclofenac, offering enhanced therapeutic outcomes for patients managing pain and inflammation. Further optimization of formulation parameters and clinical investigations are warranted to validate the clinical efficacy and safety of naringin-enhanced aceclofenac formulations.