A Comparative Study to access the accuracy of DIPSI method and random plasma glucose testing as screening tests for GDM

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Dr. Neelima Agarwal , Dr. Manisha Gupta, Dr. Alpana Agrawal, Dr. Mamta Chahar


Background: Any degree of glucose intolerance that begins or is first noticed during pregnancy is referred to as GDM. Depending on the diagnostic standards applied and the ethnic group researched, the prevalence of GDM varies greatly. It has a negative impact on perinatal and maternal outcomes. 1–14% of people in India have GDM. There are numerous GDM diagnostic and screening procedures. Early diagnosis and treatment are crucial to averting these consequences.

Aim and Objective: The present study was aimed to compare the accuracy of DIPSI method and random plasma glucose testing as screening tests for GDM.

Methodology: After gaining approval from the Santosh University ethical committee, this prospective cohort study was carried out in the Department of Gynecology and Obstetrics at Santosh Hospital in Ghaziabad. From January 2012 to June 2013, pregnant women with singleton pregnancies who attended regular prenatal checkups between the 24th and 28th week of gestation were chosen in chronological order. In all women, the random glucose test was performed first followed by DIPSI recommended method (2 hours after a 75g oral glucose load, without regard to the time of the last meal)

Result: Out of the 700 women recruited for the study, only 576 women returned for 2-
h 75-g oral glucose tolerance test (OGTT) and completed the study. he Age (mean±SD) of the
participants was 25.3±3.9 . The Age (mean±SD) of women diagnosed having GDM was 27.1±4.1.

Comparison of accuracy measures resulted in higher sensitivity in favour of the DIPSI screening test compared with the random glucose test (90.2% [95% CI 78.6– 96.7] vs. 15.7% [7.1 – 28.6]). The area under the ROC curve was larger for the DIPSI test (0.97 [0.95– 0.98]) than for the random glucose test (0.76 [0.72– 0.79]).

Conclusion: Study concluded that the DIPSI approach would be used to develop a community-based public health program to screen for and diagnose GDM.

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