To study the use of allografts with or without vancomycin impregnation in bone reconstructive surgery

Abstract

Background: To study the use of allograft with or without vancomycin impregnation in bone reconstruction surgery.

Materials & methods:      In the study, 30 patients were enrolled out of which 22 were female and 8 were male.  They were divided into two equal groups (control and study groups) comprising 15 in each group. In the study group, the bone allograft was impregnated with vancomycin while in the control group the bone allograft was not impregnated with vancomycin. Data were collected and results were analyzed using SPSS software.  The P value of less than 0.05 was taken as statistically significant.

Results: A total of 30 subjects were enrolled and they were divided into 3 broad categories. The first category had 18 patients comprised of fractures with communition and bone loss, delayed or non-unions and difficult to heal fractures. In the second category there were 8 patients with benign osteolytic lesions (3 patients each of SBC and GCT and 2 patients of ABC). The third category of patients were of miscellaneous indications with only 4 patients. The overall success rate in terms of adequate osteointegration in this study was 83.33 % , with 12 cases (80%)  out of 15 in study group and 13 cases (86.7%) out of 15 achieving adequate osteointegration and there was no significant difference (p value=1) between the two groups.

Conclusion: It was concluded that the bone allograft which was impregnated with vancomycin was able to osseointegrate adequately without any systemic or local complications.