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Nature is the best source of complementary and alternative medicine. The plant Biophytum reinwardtii has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, fraction of methanolic extract of Biophytum reinwardtii was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetyl cholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of HEMBR on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with HEMBR (i.e., 50 and 100 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats.