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Interferon-γ IFN-γ is a key player in driving cellular immunity due to its ability to regulate several protective functions to augment immune responses in infections and cancers. It can manifest its immunomodulatory effects by enhancing antigen processing and presentation, increasing leukocytes, and inducing an antibody state. For viruses, this study included the role of interferon-γ IFN- on 70 samples taken from the serum of people infected with Covid-19 and compared them with 20 samples taken from healthy people using the ELISA device. control (12.11 pg/ml) in COVID patients.