Trigonelline nanoparticles: A novel tool to restore metabolic pathways in type 2 diabetic complications.

Abstract

Disturbed insulin signalling and glucose metabolism are the key features of type 2 diabetes mellitus (T2DM) Various phytomedicines have proved their anti hyperglycemic effects. This study has been done to evaluate the therapeutic potential of trigonelline nanoparticle in diabetic complication in mice model. 4 mice groups were used for this study, control, diabetic control, treated I and treated II. Treated I was treated with trigonelline and treated II treated with trigonelline nanoparticles (TNP) for 20 days and serum insulin concentration and blood glucose level were measured as well as glucokinase (GLK), glucose 6 phosphatase (G6Pase) and glucose 6 phosphate dehydrogenase (G6PD) activity were analysed by enzymatic assay. Treated II- showed improved glucose metabolic pathways and insulin sensitivity. Serum insulin concentration, blood glucose level and GLK activity was to be found significantly increased in this group and also G6PD, G6Pase activity were significantly decreased. Recovery of glucose metabolism and insulin sensitivity is due to nanoformulation of TNP indicating its increased bioavailability and therapeutic potential, these findings are useful for future studies related to diabetic complications such as insulin signalling and insulin resistance (IR).