Mangiferin Produces Neuroprotective Effect By Attenuating H2o2 Induced Oxidative Stress In Primary Rat Hippocampal Neural Progenitor Cells.

Abstract

Background: To develop the novel therapeutic strategies for treatment of neurodegenerative disorder, the exploration of
new neuroprotective compounds can play a great role to modulate the neurogenesis and treat the neuronal defecit.
Formerly the Mangiferin (MNG), well known Xanthone glucoside and phenolic constituent of Mangifera indica has shown
to inhibit H2O2 induced oxidative damage in rat Pheochromocytoma (PC12) and nucleus pulposus (NP) cultures, but its
neuroprotective and antioxidant property on primary hippocampal neural progenitor cells (NPCs) has not evaluated.
Targeting proneurogenic approach we designed to evaluate the in vitro antioxidant and neuroprotective potential of
Mangiferin extracted from Mangifera indica.
Methodology: We examined the proliferative, antioxidant and neuroprotective actions of Mangiferin against H2O2
induced oxidative stress in primary isolated hippocampal neural progenitor cells (NPCs).
Results; The screening results displayed prominent neuroprotective effects by rescuing the hippocampal NSPCs against
H2O2 induced oxidative damage. The proliferative effects of Mangiferin on hippocampal cells was also observed in dose
dependent manner. We further demonstrated that the selected concentrations of Mangiferin did not produced any cytotoxic
effect on hippocampal cell viability and significantly inhibited reactive oxygen species generation.