Formulation And Evaluation Of Gastro Retentive Drug Delivery Systems Effective Against H Pylori

Abstract

Development of an efficient gastro retentive dosage form for stomach specific drug delivery is an actual challenge. Thus, to produce the preferred gastro retention several methods have been used, out of which, the floating drug delivery system has emerged as the best promising method. These systems provide the benefit of better absorption of drugs that are absorbed from upper part of stomach. Local action of drug is increased as the system rests in stomach for longer time. This leads to less frequent dosing and enhanced efficiency of the treatment. Good stability and better drug release as compared to other conventional dosage forms make such system more reliable. Drug absorption in GIT is a highly variable procedure and prolonging GI retention of the dosage form prolongs the time of drug absorption. Floating drug delivery system promises to be a potential approach for gastric retention. Though there are number of complications to be worked out to achieve extended GI retention, many companies are focusing toward commercializing this method.