Hepatoprotective Activity Of Ethanolic Extract Of Crinum Asiaticum Bulbs Against Ccl4 Induced Hepatotoxicity In Rats

Abstract

Objectives : Crinum asiaticum bulbs ethanol extract (EECA) was used to study the hepatoprotective activity against the CCL4 induced hepatotoxicity in rats .

Method: The hepatoprotective effects of EECA have been studied against carbon tetrachloride (CCl4 in rats. Individual rats were given EECC doses of 100, 200 and 400 mg/kg (w/w) for 14 days. On day 15, CCl4 1.25 ml/kg (ip) Induced hepatotoxicity in all rats of all groups. The silymarin (100 mg/kg p.o) administered as standard drug .The effects of EECA on activity ALP, SGOT, SGPT, and BILURUBIN (direct& total)were determined and histopathological examination of liver sections was also performed.

Result: This extract depletion of ALP, SGOT, SGPT, and BILURUBIN (direct& total)levels against CCl4-induced liver injury in rats. Histopathological evidence showed that EECA was highly hepatoprotective at 200 mg/kg and also significantly reduced biochemical liver enzyme levels.

Conclusion: Recent research results clearly demonstrate that EECA has hepatoprotective effects against CCl4induced hepato toxicity in rats .