Celecoxibin Bulk Drug And Its Tablet Formulation Subjected To Forced Degradation Study

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Dr.Sushil D.Patil
Sanket Pawar


The Celecoxib drug were subjected to forced degradation conditions and the formed degradation products were well separated and resolved from the drug and excipients on SunFire C18 column (250 × 4.6 mm, 5 μ) using blend of Acetonitrile: Water (80: 20 v/v) pH 7.0 in isocratic mode at a flow rate of 1.0mL/min at an ambient temperature of 28 °C with the detection wavelength at 251nm. The retention time of Celecoxib was found 4.32 min. The linearity was performed in the concentration range of 20-100 ppm with correlation factor of 0.999 for Celecoxib. The percentage purity of Celecoxib tablet was found 99.98%.The drug was found to degrade under acid, alkali condition but found stable under photolytic conditions

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Author Biographies

Dr.Sushil D.Patil

MET’s Institute of Pharmacy, Department of Pharmaceutical Chemistry, Bhujbal Knowledge City, Nashik S.P.P University, Pune, Maharashtra,Mobile no.8007827080

Sanket Pawar

Savitribai Phule Pune University, Pune, Maharshtra state, India