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The hepatoprotective effects of Adina cordifolia, a member of the Rubiaceae family, were studied in Wister rats that had sustained liver injury due to ethanol (AEAC) and its aqueous extract (AQEAC). When given at a dose of 500 mg/kg of body weight, AEAC and AQEAC were shown to have hepatoprotective effects, notably lowering blood SGPT, SGOT, alkaline phosphatase, and total bilirubin while significantly increasing total protein. Additional proof of the hepatoprotective effect was found through histopathological analyses of liver tissue. Serum enzyme activities were significantly elevated in ethanol-treated rats' blood samples, indicating liver damage from the ethanol, while they were significantly decreased in animals given AEAC or AQEAC, suggesting that the hepatic cells in the latter group were protected from the ethanol-induced hepatocellular injury. Both AEAC and AQEAC were successful, with benefits comparable to those of the popular drug silymarin.