Synthesis and Characterization and Biological Activity of Some New 3-Amino-2-Phenyl-(3H)4-Quinazolinone Derivatives

Abstract

In this study, phenylquinazoline-4-(3H)one, one of the significant heterocyclic compounds, is chosen to prepare many of its derivatives, which are considered Schiff bases, by reacting the heterocyclic compound with a number of aromatic aldehyde derivatives, including salicyaldehyde, piperonal, and vanillin, as well as ketone derivatives, including acetophenone, o-hydroxyacetophenone, p-nitroacetophenone, 2-bromoacetophenone, p-chloroacetophenone, and m-nitroacetophenone to prepare many Schiff bases, which are considered very important in organic and inorganic reactions, to prepare derivatives that have pharmaceutical, industrial, and agricultural applications. These prepared compounds were characterized using multiple techniques, including physical and functional techniques, to obtain their expected composition.