Synthesis Of Novel Pyrrolo [2,3-D] Pyrimidinehydrazine Derivatives Bearing Pyrrole Moiety for Evaluation as Antimicrobial Agents

Abstract

The pyrrolopyrimidinehydrazone was used as a precursor in the synthesis of pyrrolo [2, 3-d] pyrimidinehydrazide compounds. Elemental analysis, infrared spectroscopy, ¹H/¹³C NMR, and UV spectral data were used to confirm the structures of these substances. All of the newly synthesized compounds were evaluated for cytotoxicity against artemia salina in vitro. All novel compounds were also tested for antimicrobial activity in vivo. When compared to streptomycin and fluconazole, several derivatives demonstrated potential antimicrobial activity. We investigate and discuss the structure-activity relationships and antimicrobial activities of these compounds in this article.