A Study Of Cd4 Count Profile In Pulmonary And Extra Pulmonary Tuberculosis In A Tertiary Health Care Centre

Abstract

Background: Tuberculosis (TB) is caused by bacteria (Mycobacterium tuberculosis) which most commonly affects the lungs. Tuberculosis is curable and preventable. Replication of mycobacterium is more common  in immunocompromised condition, CD4 T cells are also known as T helper cells which are functional cells for executing immune function. T-cells are a subset of white blood cells that play an important role in the body's immune system. CD4 is a type of protein found on the certain immune cells like T-cells, macrophages, and monocytes. In this study CD4 count in TB patients are assessed.  

Materials And Methods: This cross sectional study was conducted at Sri Ramachandra Medical College and Hospital. Centre, Sample size was 74.

Result: Out of 74 patients 49% are below 40 years of age, 32% are between 41-60 years and 19% belong to above 60 years. 20% patients had CD4 count of above 1000, 35% had CD4 count below 400 and 44 % patients had CD4 count of between 400-1000.

Conclusion: Statistically significant reduction in CD4 and ALC count in smokers is Suggestive of Smoking Interferes with pulmonary immunology.