Transferosome: A Vesicular Transdermal Delivery System For Enhanced Drug Permeation Of Antihypertensive Drug Bisoprolol Fumarate

Abstract

The barrier function of the skin limits transdermal medication delivery. Vesicular systems are one of the most contentious mechanisms for delivering active compounds transdermally. The discovery of elastic vesicles such transferosomes, ethosomes, cubosomes, phytosomes, and others reignited interest in creating transdermal delivery systems. Transferosomes are ultradeformable vesicles for transdermal applications consisting of a lipid bilayer with phospholipids and an edge activator and an ethanol/aqueous core. In another definition transferosmes are the carriers for the targeted drug delivery system. Transferosomes are the specialised types of liposomes consist of phosphatidylcholine and an age activator. Bisoprolol is a β-blocker selective cardiovascular drug. It is given in salt form of fumarate for the management of hypertension and angina pectoris.  On oral administration, bioavailability of drug is very poor because of extensive first pass metabolism.  Delivery of bisoprolol fumarate via transdermal route would minimize some of the deficiencies associated with the oral delivery and increase the bioavailability of the drug. This review will focus on an innovative drug delivery system for permeation of an antihypertensive drug with low permeability.