Herbal Drugs Interventions In Diabetic Nephropathy

Abstract

Chronic hyperglycemia, which arises from abnormal insulin secretion, function, or both, is a hallmark of a group of metabolic illnesses known as Diabetes mellitus.The kidney damage that strikes diabetics is referred to as diabetic nephropathy (DN), with glomerulus thickening being the first observable symptom of the condition. There are two stages of diabetic kidney disease (DN): microalbuminuria and macroalbuminuria, the conditions in which the kidney leaks more serum albumin than usual into the urine. As DN advances, more glomeruli are observed to be damaged by progressive nodular glomerulosclerosis, possibly by enhanced. The aetiology of DN has been linked to a number of signalling pathways, including increased production of reactive oxygen species (ROS), advanced glycation end products (AGEs), and protein kinase C (PKC) activation.Effective techniques to avoid the pathogenesis of diabetic nephropathy should be developed, as the number of diabetic patients with end-stage renal disease is still rising despite the effectiveness of therapeutic alternatives such as glycemic management, hypertension medication, antioxidants and hyperlipidemia in preventing DN. Herbal drugs present a great potential in the treatment and prevention of DN. In this article, we provide an overview of the many signalling pathways that are implicated in the development of DR. In the review, a variety of herbal medications for the treatment of DN have also been covered