Formulation And Evaluation Of Mouth Dissolving Film Of An Antihypertensive Drug

Abstract

Objective: The present research work is focused to formulate and evaluate mouth dissolving film of an antihypertensive drug to enhance the convenience and compliance by the Geriatric patients.

Methods: The formulation was prepared using Lisinopril drug, and excipients such as HPMC E5, glycerine, aspartame, citric acid, etc. by solvent casting method. The formulations were subjected to evaluation characteristics such as appearance, weight variation, thickness, folding endurance, surface pH, tensile strength, disintegration time, drug content, and in-vitro drug release studies. 

Results: All the prepared A1 to A9 batches shown pH was found in the range of 6.5 to 6.7, disintegration time was found in range of 19.49 to 24.38 seconds, drug content was found in range of 88 to 95%, and % drug release was found in range of 82.02 to 95.20%. As compared to other formulation batches, A6 batch selected as an optimized formulation because it gave the highest drug content that is 95%, and highest drug release of 95.20% after 70 seconds. 

Conclusion: It concluded that the mouth fast dissolving films of Lisinopril for control of Hypertension could be successfully formulated using HPMC E5 polymer by solvent casting method.