Studies On Co crystallization Of Curcumin: Solid State Characterization

Abstract

The poor solubility and dissolution rate is major constrain in oral delivery of most of drugs. The most of drug synthesized nowadays are BCS class II and IV drugs. Many scientific investigators have utilized various approaches for dissolution rate enhancement of drug. The formulation of cocrystals is recently explored way for solubility enhancement of drug. Curcumin is naturally obtaining drug used in management of various disease. The poor solubility is major limitation associated with oral delivery of curcumin. Thus, present study has planned to formulate curcumin cocrystals.

The cocrystals of curcumin were prepared using various coformer by solvent evaporation method. The formulated cocrystals showed enhanced saturation solubility than pure drug and more drug release than pure drug. Thus, cocrystals could be promising alternative for delivery of drug.