Serological And Immunological Study Of Cytomegalovirus In Patients With Rheumatiod Arthriris And Cardiovascular Disease

Abstract

Cytomegalovirus (CMV) infection has been implicated in various chronic diseases, including rheumatoid arthritis (RA) and cardiovascular disease (CVD). In this study, we aimed to investigate the serological and immunological aspects of CMV infection in patients with RA and CVD. Serum samples from patients with RA, CVD, and healthy controls were tested for CMV-specific antibodies using serological assays. Additionally, the levels of pro-inflammatory cytokines were measured in the serum to assess the immune response to CMV infection. Our results showed a higher prevalence of CMV IgG antibodies in patients with RA and CVD compared to the healthy controls. Furthermore, patients with RA and CVD had elevated levels of pro-inflammatory cytokines, suggesting an inflammatory response to CMV infection. These findings highlight the potential role of CMV in the pathogenesis of RA and CVD and emphasize the importance of investigating the immunological aspects of CMV in these conditions.