The Role Of Biologic Therapies In Improving Joint Health In Autoimmune Arthritis

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Shayim Saud Alanazi
Ibrahim Hassan Almalki
Abdulaziz Amin Alandijani
Hassan Mohammed Thubab
Haifa Saud Alkheledan
Shahad Ali Alsufyani
Salma Awadh Alharthi
Abdullah Mansoor Al nass
Ibrahim Ali AlSultan
Ali Mohammed Alshahrani
Abdullah Fuad Aborukbah

Abstract

The field of autoimmune arthritis treatment has seen changes due to the introduction of therapies transforming how conditions like rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) are managed. For RA, starting treatments like tumor necrosis factor alpha (TNF α) inhibitors, interleukin 6 (IL 6) receptor antagonists, and Janus kinase (JAK) inhibitors are crucial for achieving remission and preventing joint damage. JAK inhibitors like tofacitinib offer options with administration. Managing Psoriatic arthritis involves using TNF α inhibitors as therapies, while IL-17A inhibitors address joint and skin issues comprehensively. Tailoring treatment plans based on characteristics leads to better results in this complex condition. Ankylosing spondylitis poses challenges where TNF α inhibitors and IL 17A inhibitors vital in reducing disease activity and enhancing spinal mobility. Incorporating physical therapy highlights the approach needed for outcomes in ankylosing spondylitis. The conversation explores the intricacies of using therapies, highlighting how clinical management continues to evolve. Regular monitoring, involving patients in decision-making, and having an understanding of backgrounds are key elements for navigating the ups and downs linked with biological treatments. To sum up, the analysis highlights how biological treatments have significantly changed the way autoimmune arthritis is handled. Tailored approaches that take into account the nature of the disease and individual patient choices play a role in enhancing joint health and overall quality of life.


 

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Author Biographies

Shayim Saud Alanazi

Department of Orthopaedic, King Khalid Hospital, Tabuk, Saudi Arabia

Ibrahim Hassan Almalki

Ain Shams Primary Healthcare Center, Mecca Health Cluster, Mecca, Saudi Arabia

Abdulaziz Amin Alandijani

Department of Pediatric Emergency, Al Aziziya Children Hospital, Jeddah, Saudi Arabia

Hassan Mohammed Thubab

Occupational Health Department, King Fahad Central Hospital, Jazan, Saudi Arabia

Haifa Saud Alkheledan

Public Health, Riyadh First Health Cluster, Riyadh, Saudi Arabia

Shahad Ali Alsufyani

Wast Almadinah Primary Healthcare Center, Ministry of Health, Taif, Saudi Arabia

Salma Awadh Alharthi

Department of Internal Medicine, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia

Abdullah Mansoor Al nass

Department of Family Medicine, Qatif Health Network, Qatif, Saudi Arabia

Ibrahim Ali AlSultan

Department of Family Medicine, Qatif Health Network, Qatif, Saudi Arabia

Ali Mohammed Alshahrani

Department of Nephrology, King Abdulaziz Hospital, Jeddah, Saudi Arabia

Abdullah Fuad Aborukbah

Department of Orthopedics, Al Thager Hospital, Jeddah, Saudi Arabia