Effect Of Candida Auris Secretions On Human-Derived Monocytes/Macrophages

Abstract

Candida auris is emerging multidrug-resistant fungal pathogen poses a serious to human health worldwide. This study aims to investigate the effect of Candida auris secretions on human-derived monocytes/macrophages. Monocytes/macrophages play a crucial role in the immune response by phagocytosing and killing pathogens. Understanding how Candida auris secretions impact these immune cells can provide valuable insights into the pathogenesis of this opportunistic fungus. In this study, we utilized various techniques to evaluate the response of human monocytes/macrophages to Candida auris secretions, including cytokine production, phagocytosis assays, and gene expression analysis. Our findings suggest that Candida auris secretions induce a pro-inflammatory response in monocytes/macrophages, leading to increased cytokine production and altered gene expression patterns. Additionally, Candida auris secretions impair the phagocytic ability of monocytes/macrophages, thereby evading the immune response. This study sheds light on the immunomodulatory effects ofa auris secretions on human-derived monocytes/macrophages, highlighting the importance of understanding-pathogen interactions fungal infections.