Assessing The Safety Profile Of Carica Papaya Leaves And Seeds On Hepatic And Renal Function In Healthy Rabbits

Abstract

Objective: To assess the impact of Carica papaya leaves and seeds on hepatic and renal function in a controlled rabbit model.

Methodology: In a 45-day experimental study at Baqai Medical University, Karachi, 18 healthy adult rabbits were allocated into five groups. All groups received varying doses of papaya seed or leaf extracts. Liver and renal function assessments were performed at 15-day intervals, providing insights into the impact of Carica papaya extracts on these vital physiological functions.

Results: The administration of papaya extracts demonstrated a generally favorable safety profile, with no disruption to liver enzymes and renal biochemistries. However, the group receiving papaya seed extract at 500mg exhibited a noteworthy increase in albumin levels. While this may suggest a potential risk of dehydration, it did not impact liver synthetic function. Notably, renal function remained within clinically acceptable ranges across all groups, emphasizing the overall safety of the papaya extracts.

Conclusion: The findings suggest that Carica papaya extract, particularly from leaves, holds therapeutic potential for promoting liver and kidney health. Importantly, the observed effects were without significant adverse consequences. These results provide valuable insights into the safety and potential benefits of Carica papaya extracts, laying the foundation for further research and exploration of their applications in supporting hepatic and renal functions.